Drug as a weapon

An acetylcholinesterase inhibitor is allegedly used to poison Russian opposition leader

photo by https://www.instagram.com/yulia_navalnaya/?hl=en
Time magazine 2012

Donepezil is only one of the examples of an acetylcholinesterase inhibitor (that comes to mind). It was approved in the US for Dementia or Alzheimer’s disease in 1996. Since the widespread use in the patients’ population, and relatively low cost (US$1.3 per pill) allowed to study well the side effects and pharmacokinetics. The drug induces REVERSIBLE changes by inactivating the cholinesterases in the brain. Plasma Donepezil concentrations decline with a half-life of approximately 70 h to clear the drug from the body. Time to steady-state of body’s systems after exposure to Donepezil is 15 days.

Symptoms of overdose may include :

Unintentional poisonings

learner, writer, biotech investor, research translation, drug development, genetics. 4-lingual.

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